Structure-Informed Protein Language Model

Closed weights Mila - Quebec AI (originally Montreal Institute for Learning Algorithms),University of Montreal / Université de Montréal,IBM Research,HEC Montreal,CIFAR AI Research 650M parameters February 2024

No estimate

No hardware requirements for this model

The weights for this model have not been published, so it cannot be downloaded or run on your own hardware at any size. It is reachable only through its provider, and no graphics card changes that.

On record

Full specification

Everything on record for this model. Most of it describes how it was trained rather than how it runs — useful context for judging how much work went into it, and how it compares with models built at a different scale.

Origin

Who built this model, where, and when it was published.

Organisation
Mila - Quebec AI (originally Montreal Institute for Learning Algorithms),University of Montreal / Université de Montréal,IBM Research,HEC Montreal,CIFAR AI Research
Organisation type
Academia,Academia,Industry,Academia,Research collective
Country
Canada, United States of America
Published
7 February 2024
Authors
Zuobai Zhang, Jiarui Lu, Vijil Chenthamarakshan, Aurélie Lozano, Payel Das, Jian Tang

What it does

The problem areas the model was built for. A model can carry several of each.

Domain
Biology
Task
Protein or nucleotide language model (pLM/nLM)
Base model
ESM2-650M

Size

How large the model is and how much data it was trained on. Parameters are the figure that decides whether it fits on a given graphics card.

Parameters
650M
Training data
tokens

Fine-tuning: 12,312 proteins × 300 residues = 3.7 × 10^6 tokens

Epochs
50

How it is classified

Labels the source dataset applies when tracking notable models, and how confident it is in the entry.

Record confidence
Likely
Citations
15

Sources

Where this record came from and when it was last checked.

Reference
Structure-Informed Protein Language Model
Last updated
25 May 2026

What the numbers mean

Where it came from

Structure-Informed Protein Language Model was published by Mila - Quebec AI (originally Montreal Institute for Learning Algorithms),University of Montreal / Université de Montréal,IBM Research,HEC Montreal,CIFAR AI Research, in the country recorded as Canada, during February 2024. It comes out of an organisation categorised as academia,Academia,Industry,Academia,Research collective.

It works in the domain of Biology, and is recorded as performing the task of protein or nucleotide language model (pLM/nLM).

Its starting point was an existing base model, ESM2-650M. That is why it shares the base model's general shape and size.

Its weights were never published, so it can only be reached through its provider. No graphics card changes that.

Answers

Structure-Informed Protein Language Model — common questions

01

Structure-Informed Protein Language Model— when was it released?

It was published in February 2024. Capability per parameter has improved considerably since, so a newer model of the same size is often the better use of the same hardware.

02

Structure-Informed Protein Language Model— what is it used for?

It works in the domain of Biology, and is recorded as handling the task of protein or nucleotide language model (pLM/nLM). These are the areas it was designed around; they describe intent rather than a hard boundary.

03

Structure-Informed Protein Language Model— what GPU do I need to run it?

None. This is a closed model — its weights were never published, so it cannot be downloaded or run on your own hardware at any price. It is reachable only through its provider.

04

Structure-Informed Protein Language Model— is it open source?

The licensing was never recorded in our source data. We treat unstated licensing as closed, because an unrecorded licence is not one to rely on.

05

Structure-Informed Protein Language Model— how many parameters does it have?

It has a parameter count of 650M. That figure is the total, and it is what decides how much memory the model needs — roughly half a gigabyte per billion at the compression most people use.

06

Structure-Informed Protein Language Model— who created it?

It was published by Mila - Quebec AI (originally Montreal Institute for Learning Algorithms),University of Montreal / Université de Montréal,IBM Research,HEC Montreal,CIFAR AI Research, based in Canada, an organisation categorised as academia,Academia,Industry,Academia,Research collective.

Source

Original publication

Record last updated 25 May 2026

The other direction

Looking at it from the other side?

This page starts from the model. If you already own a card and want to know everything it will run, start from the hardware instead.