Pro-PRIME

Closed weights Shanghai Jiao Tong University,Shanghai AI Lab,East China University of Science and Technology,Shanghai Tech University,Guangzhou Inernational Bio Island,Chinese Academy of Sciences,Shanghai Academy of Experimental Medicine 650M parameters October 2024

No estimate

No hardware requirements for this model

The weights for this model have not been published, so it cannot be downloaded or run on your own hardware at any size. It is reachable only through its provider, and no graphics card changes that.

On record

Full specification

Everything on record for this model. Most of it describes how it was trained rather than how it runs — useful context for judging how much work went into it, and how it compares with models built at a different scale.

Origin

Who built this model, where, and when it was published.

Organisation
Shanghai Jiao Tong University,Shanghai AI Lab,East China University of Science and Technology,Shanghai Tech University,Guangzhou Inernational Bio Island,Chinese Academy of Sciences,Shanghai Academy of Experimental Medicine
Organisation type
Academia,Academia,Academia,Academia,Academia
Country
China
Published
28 October 2024
Authors
Fan Jiang, Mingchen Li, Jiajun Dong, Yuanxi Yu, Xinyu Sun, Banghao Wu, Jin Huang, Liqi Kang, Yufeng Pei, Liang Zhang, Shaojie Wang, Wenxue Xu, Jingyao Xin, Wanli Ouyang, Guisheng Fan, Lirong Zheng, Yang Tan, Zhiqiang Hu, Yi Xiong, Yan Feng, Guangyu Yang, Qian Liu, Jie Song, Jia Liu, Liang Hong, Pan Tan

What it does

The problem areas the model was built for. A model can carry several of each.

Domain
Biology
Task
Protein design

Size

How large the model is and how much data it was trained on. Parameters are the figure that decides whether it fits on a given graphics card.

Parameters
650M
Training data
tokens

96,000,000 sequences × 300 residues/sequence = 28,800,000,000 tokens (2.88 × 10¹⁰)

Epochs
7

Training compute

The arithmetic performed to train the model, measured in floating-point operations. It is a measure of what the training run cost, not of how fast the finished model answers you.

Training compute
8.2 × 10²⁰ FLOP

Tokens per step; 4096*8*32=1048576 Total training tokens 1048576*200000=209715200000 Epochs: 209715200000 / 28800000001 = 7.28 FLOP: 6*650000000*209715200000=8.1788928e+20

How it was established
Hardware

How it is classified

Labels the source dataset applies when tracking notable models, and how confident it is in the entry.

Record confidence
Confident
Citations
1

Sources

Where this record came from and when it was last checked.

Reference
Pro-PRIME: A general Temperature-Guided Language model to engineer enhanced Stability and Activity in Proteins
Last updated
28 November 2025

What the numbers mean

Background

Pro-PRIME was published by Shanghai Jiao Tong University,Shanghai AI Lab,East China University of Science and Technology,Shanghai Tech University,Guangzhou Inernational Bio Island,Chinese Academy of Sciences,Shanghai Academy of Experimental Medicine, in the country recorded as China, during October 2024. It comes out of an organisation categorised as academia,Academia,Academia,Academia,Academia.

It works in the domain of Biology, and is recorded as performing the task of protein design.

This is a closed model: the trained values stayed with whoever produced them, and there is no local version to run.

How it was trained

The training run consumed about 8.2 × 10²⁰ FLOP. That figure measures what producing the model cost, and has no bearing on how fast it answers.

Answers

Pro-PRIME — common questions

01

Pro-PRIME— how much compute was used to train it?

Training consumed around 8.2 × 10²⁰ FLOP. That measures what producing the model cost and says nothing about how quickly it answers once trained — inference speed comes from memory bandwidth, not from the training budget.

02

Pro-PRIME— what GPU do I need to run it?

None. This is a closed model — its weights were never published, so it cannot be downloaded or run on your own hardware at any price. It is reachable only through its provider.

03

Pro-PRIME— is it open source?

The licensing was never recorded in our source data. We treat unstated licensing as closed, because an unrecorded licence is not one to rely on.

04

Pro-PRIME— how many parameters does it have?

It has a parameter count of 650M. That figure is the total, and it is what decides how much memory the model needs — roughly half a gigabyte per billion at the compression most people use.

05

Pro-PRIME— who created it?

It was published by Shanghai Jiao Tong University,Shanghai AI Lab,East China University of Science and Technology,Shanghai Tech University,Guangzhou Inernational Bio Island,Chinese Academy of Sciences,Shanghai Academy of Experimental Medicine, based in China, an organisation categorised as academia,Academia,Academia,Academia,Academia.

06

Pro-PRIME— when was it released?

It was published in October 2024. Capability per parameter has improved considerably since, so a newer model of the same size is often the better use of the same hardware.

07

Pro-PRIME— what is it used for?

It works in the domain of Biology, and is recorded as handling the task of protein design. Models frequently carry more than one of each, and the tags describe purpose rather than capability limits.

Source

Original publication

Record last updated 28 November 2025

The other direction

Looking at it from the other side?

This page starts from the model. If you already own a card and want to know everything it will run, start from the hardware instead.